CST, 5937T, VMS1 (D10E6) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying VMS1 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, VMS1 (D10E6) Rabbit Monoclonal Antibody (CST #5937) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity VMS1 (D10E6) Rabbit Monoclonal Antibody detects endogenous levels of total VMS1 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of mouse VMS1 protein. Background Mitochondria are membrane-bound subcellular organelles critical to many functions in eukaryotic cells (1). Several mechanisms have been found to play a role in mitochondria quality control (2). A recent study identified mitochondria-associated protein degradation as one such mechanism (1,2). The study showed that VMS1 (VCP/Cdc48-associated mitochondrial stress-responsive) interacts with VCP/Cdc48 and Npl4, two components in the endoplasmic reticulum-associated protein degradation pathway, and mediates the degradation of damaged mitochondrial proteins under stress conditions (1). Defective VMS1 compromises mitochondrial functions and cell viability (1). Alternate Names 1300008P06Rik; 2810025E10Rik; ankyrin repeat and zinc finger domain containing 1; ankyrin repeat and zinc finger domain containing protein; Ankyrin repeat and zinc finger domain-containing protein 1; ANKZ1; Ankzf1; D1Ertd161; D1Ertd161e; tRNA endonuclease ANKZF1; VMS1 Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 100 Source/Isotype: Rabbit IgG