CST, 59568S, MARCKSL1 (D4I9P) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MLP. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MARCKSL1 (D4I9P) Rabbit Monoclonal Antibody (CST #59568) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MARCKSL1 (D4I9P) Rabbit Monoclonal Antibody recognizes endogenous levels of total MARCKSL1 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro186 of human MARCKSL1 protein. Background Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS/ MARCKS-like protein 1/ MacMARCKS/ MLP/ MRP) is a widely expressed membrane-bound PKC substrate involved in multiple cellular functions (1). MARCKSL1 is a MARCKS homolog that also serves as a substrate for PKC, and regulates cytoskeletal dynamics, migration, adhesion, and proliferation. In response to phosphorylation by JNK, MARCKSL1 regulates migration and actin dynamics in neuronal and prostate cancer cells (2). In the developing retina, MARCKSL1 regulates cell proliferation, and its expression decreases as retinal development progresses (3). Researchers have shown that MARCKSL1 may serve as a prognostic marker in lymph node-negative breast cancer (4). Alternate Names F52; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS like 1; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MARCKSL1; MLP; MLP1; MRP Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 40 Source/Isotype: Rabbit IgG