CST, 60613S, Coronin 1A (D7M3N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying coronin 1A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Coronin 1A (D7M3N) Rabbit Monoclonal Antibody (CST #60613) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Coronin 1A (D7M3N) Rabbit Monoclonal Antibody recognizes endogenous levels of total coronin 1A protein. Based on the sequence of the immunogenic peptide, this antibody is not expected to cross-react with other coronin protein family members. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human coronin 1A protein. Background The coronin family of actin-binding proteins regulates a variety of cellular functions, including migration, phagocytosis, and cytokinesis. Coronin 1A is highly expressed in lymphocytes, and is required for appropriate immune regulation in mice and humans. Researchers are investigating coronin 1A as a potential therapeutic target for autoimmune diseases and lymphoid cancers (1,2). Coronin 1A affects bone resorption through its regulation of lysosome fusion and secretion of cathepsin K in osteoclasts (3). In the nervous system, coronin 1A has been shown to regulate GPCR signaling and neurite outgrowth (4,5). Alternate Names CLABP; Clipin-A; CLIPINA; COR1A; CORO1; CORO1A; coronin 1A; coronin-1; Coronin-1A; Coronin-like protein A; Coronin-like protein p57; coronin, actin binding protein, 1A; coronin, actin-binding protein, 1A; coronin, actin-binding, 1A; FLJ41407; HCORO1; IMD8; MGC117380; p57; TACO; Tryptophan aspartate-containing coat protein Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 60 Source/Isotype: Rabbit IgG