CST, 60763S, TMOD1 Antibody

Polyclonal Antibody for studying TMOD1. Validated for Western Blotting. Highly specific and rigorously validated in-house, TMOD1 Antibody (CST #60763) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TMOD1 Antibody recognizes endogenous levels of total TMOD1 protein. This antibody is not predicted to cross-react with other TMOD protein family members (TMOD2-4). Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro353 of human TMOD1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Tropomodulin-1 (TMOD1) belongs to a conserved family of cytoskeletal proteins (TMOD1-4) that play an important role in modulating actin cytoskeleton dynamics. TMOD proteins function as actin capping proteins, which stabilize actin filaments by inhibiting both elongation and depolymerization (1). While many proteins have been identified that cap the rapidly growing barbed end of actin filaments, TMODs are the only proteins thus far identified that cap the slowly growing pointed end (2). A research study in triple-negative breast cancer cells identified TMOD1 as a target of NF-κB signaling, and showed that increased TMOD1 expression was associated with enhanced tumor growth in a mouse xenograft model (3). Molecular expression of was also identified as part of a unique gene expression signature that could discriminate ALK-negative anaplastic large-cell lymphoma from other malignancy subtypes (4). Alternate Names D9S57E; E-Tmod; e-tropomodulin; Erythrocyte tropomodulin; ETMOD; TMOD; TMOD1; tropomodulin 1; Tropomodulin-1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 45 SOURCE: Rabbit