CST, 62043S, TRBP2 (D7C8K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TRBP2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TRBP2 (D7C8K) Rabbit Monoclonal Antibody (CST #62043) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TRBP2 (D7C8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRBP2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro119 of human TRBP2 protein. Background Trans-activation response (TAR) RNA binding protein (TRBP2) was initially discovered as a double stranded RNA binding protein (dsRBP) that bound TAR RNA sequences of the HIV-1 virus (1, 2). TRBP2 can bind to and inhibit the phosphorylation of protein kinase PKR, which leads to increased activation of the HIV-1 long terminal repeat (3,4). Along with PACT, TRBP2 is one of the dsRBPs in the RNA-induced silencing complex (RISC), where it plays a critical role in recruiting Ago2 to the miRNA bound by Dicer. (5-8). Alternate Names LOQS; RISC-loading complex subunit TARBP2; TAR (HIV-1) RNA binding protein 2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; TARBP2 subunit of RISC loading complex; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein; TRBP; TRBP1; TRBP2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 44 Source/Isotype: Rabbit IgG