CST, 62263S, A2BP1 (E8R9Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying A2BP1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, A2BP1 (E8R9Z) Rabbit Monoclonal Antibody (CST #62263) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity A2BP1 (E8R9Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total A2BP1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro106 of human A2BP1 protein. Background Ataxin-2-binding protein 1 (A2BP1) is part of the RNA-binding Fox (RBFOX) family of splicing factors, which is composed of three members, RBFOX1 (Fox-1 or A2BP1), RBFOX2 (Fox-2 or RBM9), and RBFOX3 (Fox-3, HRNBP3, or NeuN). RBFOX proteins regulate splicing of many neuronal transcripts by binding the sequence (U)GCAUG in mRNA precursors (1). Human A2BP1 was first identified through its interaction with Ataxin-2, the protein mutated in spinocerebellar ataxia type II. It has since been shown to play a role in the etiology of autism spectrum disorder (ASD) (1,2). Impaired A2BP1 function was found to cause abnormal corticogenesis during brain development. The abnormal process may underlie the basic pathophysiology of ASD and other neurodevelopmental disorders and may contribute to the emergence of the clinical symptoms of patients with gene abnormalities (3). The expression of A2BP1 is restricted to neurons, heart, and muscle (1,4). Alternate Names 2BP1; A2BP; A2BP1; ataxin 2-binding protein 1; Ataxin-2-binding protein 1; FOX-1; Fox-1 homolog A; fox-1-like RNA-binding protein 1; FOX1; FOX1A; hexaribonucleotide binding protein 1; Hexaribonucleotide-binding protein 1; HRNBP1; RBFOX1; RFOX1; RNA binding fox-1 homolog 1; RNA binding protein fox-1 homolog 1; RNA binding protein, fox-1 homolog 1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 50, 60 Source/Isotype: Rabbit IgG