CST, 62387S, COX10 Antibody

Polyclonal Antibody for studying COX10. Validated for Western Blotting. Highly specific and rigorously validated in-house, COX10 Antibody (CST #62387) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity COX10 Antibody recognizes endogenous levels of total COX10 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp31 of human COX10 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background COX10 is an assembly factor for cytochrome c oxidase (COX, also known as complex IV) in the mitochondrial electron transport chain (1,2). Studies show that, when the gene encoding the β2-adrenergic receptor ( ) is deleted, increased oxidative phosphorylation in endothelial cells inhibits angiogenesis. Deletion of prevents the metabolic switch to oxidative phosphorylation in endothelial cells deleted of causing angiogenesis and cancer progression (2). In addition, COX10 contributes to T cell quiescence exit and is critical for T cell activation (3). Alternate Names COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor; cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10; cytochrome c oxidase assembly homolog 10; cytochrome c oxidase assembly protein; cytochrome c oxidase subunit X; heme A: farnesyltransferase; Heme O synthase; Protoheme IX farnesyltransferase, mitochondrial Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 49 SOURCE: Rabbit