CST, 62577S, OMP25/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SYNJ2BP. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, OMP25/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody (CST #62577) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity OMP25/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total OMP25/SYNJ2BP protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human OMP25/SYNJ2BP protein. Background Synaptojanin-2 binding protein (SYNJ2BP), also known as OMP25, is a mitochondrial outer membrane protein that acts as a signaling hub, regulating crucial processes in the brain, including neuron function and inter-organelle communication. A key function of SYNJ2BP is managing the contact between mitochondria and the endoplasmic reticulum (ER), known as mitochondrial-ER contact sites (MERCs) (1). Specifically in neurons, SYNJ2BP and Synaptojanin-2 (SYNJ2) form a tethering complex that latches PTEN induced putative kinase 1 (PINK1) mRNA onto the mitochondria. This specialized mechanism enables the local translation of PINK1 in distal parts of the cell, ensuring that distant mitochondria receive a steady supply of the protein required to activate mitophagy (2). By regulating the contact points between the ER and mitochondria in the liver, SYNJ2BP also plays a role in regulating hepatic lipid flux (3). Alternate Names activin receptor interacting protein 5; ARIP2; FLJ11271; FLJ41973; Mitochondrial outer membrane protein 25; OMP25; SYJ2B; synaptojanin 2 binding protein; Synaptojanin-2-binding protein; SYNJ2BP Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 16 Source/Isotype: Rabbit IgG