CST, 62883S, HOXD9 Antibody

Polyclonal Antibody for studying HOXD9. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, HOXD9 Antibody (CST #62883) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity HOXD9 Antibody recognizes endogenous levels of total HOXD9 protein. Species Reactivity: Human, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human HOXD9 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Homeobox protein Hox-D9 (HOXD9) is a sequence-specific transcription factor that is part of a developmental regulatory program that provides cells with specific positional identities on the anterior-posterior axis. HOXD9 is developmentally expressed in structures of either mesodermal or neuro-ectodermal origin, such as developing limbs, gonads, and the central nervous system (1-6). HOXD9 plays a critical role in regulation of limb development, neuronal development, and development of mammary glands and gonads in many organisms (1-6). The HOXD9 gene promoter is found to be hypermethylated and silenced in multiple types of cancer, including breast cancer, melanoma brain metastases, and cholangiocarcinomas (7-9). In addition, HOXD9 expression is increased in other types of cancer, including human glioblastomas and astrocytomas, where expression appears to drive growth of the tumors (10). Alternate Names homeo box D9; homeobox D9; Homeobox protein Hox-4C; Homeobox protein Hox-5.2; Homeobox protein Hox-D9; Hox-4.3; Hox-4.3, mouse, homolog of; Hox-5.2; HOX4; HOX4C; HOXD9; HXD9 Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 42 SOURCE: Rabbit