CST, 63607S, Total Neurogranin Matched Antibody Pair

Matched Antibody Pair for studying neurogranin in the research area. Product Usage Information Matched Antibody Pairs consist of capture and detection antibodies that bind to non-overlapping epitopes. For specific identification of the capture and detection antibodies in this pair, please refer to the data figure caption. Optimal dilutions/concentrations should be determined by the end user. Formulation Supplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. Storage Store at -20ºC. This product will freeze at -20ºC so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles . A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance. Background Neurogranin is a small neuronal protein that binds to calmodulin in the absence of Ca (1,2). Calmodulin binds Ca and acts as a Ca sensor to drive Ca -dependent signal transduction pathways by modulating its interaction with various kinases and phosphatases (3). In the postsynaptic compartment of the neuron, Ca  is carefully regulated and is a critical regulator of synaptic function and plasticity (4). Neurogranin is primarily expressed in the brain and is enriched in somato-dendritic compartments of projection neurons in various regions of the brain (5). Postsynaptically-enriched neurogranin likely influences Ca  or Ca /calmodulin-dependent neuronal functions, including synaptic plasticity, by binding to and releasing calmodulin in a Ca -dependent manner (6-9). Genetic variants in the gene encoding neurogranin, are linked to several neuropsychiatric diseases, including schizophrenia (10). Interestingly, increase in cerebrospinal fluid neurogranin is correlated with neurodegenerative disease progression, which suggests that neurogranin could act as a biomarker for diseases like Alzheimer's disease (11). Alternate Names calmodulin-binding protein; hng; NEUG; NEUG(55-78); Neurogranin; neurogranin (protein kinase C substrate, RC3); Ng; NRGN; protein kinase C substrate; RC3 Specification REACTIVITY: H M R