CST, 64094T, VEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying VEGFR1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, VEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody (CST #64094) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity VEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody recognizes endogenous levels of total VEGF Receptor 1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human VEGF Receptor 1 protein. Background The vascular endothelial growth factor (VEGF) receptor (VEGFR-1, Flt-1) is a 180 kDa receptor tyrosine kinase belonging to the VEGFR (Flt) family (1-3). The receptor is comprised of seven extracellular Ig-like domains, a single transmembrane region and cytoplasmic tail containing the active kinase domain (1,2). VEGFR-1 plays an important role in endothelial cell function and normal vascular development, as well as in hematopoietic function (2,3). VEGF-A is a high affinity ligand of VEGFR-1. VEGFR-1 also binds VEGF-B and PLGF (2). Ligand binding results in very little VEGFR-1 kinase activation, and VEGFR-1/VEGF-A binding negatively regulates VEGF function by diverting the growth factor from other functional VEGF receptors (3). Alternate Names FLT; FLT-1; FLT1; fms related receptor tyrosine kinase 1; fms related tyrosine kinase 1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGFR-1; VEGFR1; VGFR1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 180, 200 Source/Isotype: Rabbit IgG