CST, 64184T, NCAM2 (E8J3B) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying NCAM2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NCAM2 (E8J3B) Rabbit Monoclonal Antibody (CST #64184) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity NCAM2 (E8J3B) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCAM2 protein. This antibody does not cross-react with NCAM1. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly261 of human NCAM2 protein. Background NCAM (neural cell adhesion molecule) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Two NCAM paralogs ( and ) are encoded in the mammalian genome, which encode NCAM/NCAM1 and NCAM2 proteins, respectively (1,2). As an adhesion molecule with brain-enriched expression, NCAM2 functions to drive axonal targeting, neurite branching, and synaptic development (2-4). is also genetically linked to Down syndrome and may play a role in neurodegenerative diseases such as Alzheimer's disease (2,5). Alternate Names MGC51008; N-CAM-2; NCAM-2; NCAM2; NCAM21; Neural cell adhesion molecule 2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 93, 140 Source/Isotype: IgG