CST, 64221T, PP6C (E3V2A) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PP6C. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PP6C (E3V2A) Rabbit Monoclonal Antibody (CST #64221) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PP6C (E3V2A) Rabbit Monoclonal Antibody recognizes endogenous levels of total PP6C protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly243 of human PP6C protein. Background Serine/threonine-protein phosphatase 6 (PP6) is an evolutionarily conserved and ubiquitously expressed member of the type 2A protein phosphatase family. Research studies have proposed that PP6 functions as a heterotrimeric holoenzyme complex that consists of a catalytic subunit, PP6C, and regulatory subunits (1,2). PP6 has been implicated in the regulation of numerous biological processes, such as cell-cycle progression, cell growth, and antiviral innate immune signaling (3). Indeed, research studies have demonstrated that PP6C dephosphorylates and activates Rig-I in order to facilitate type I interferon (IFN) signaling and antiviral immunity (4). Alternate Names FLJ92648; MGC12249; PP6; PP6C; PPP6; PPP6C; protein phosphatase 6 catalytic subunit; protein phosphatase 6, catalytic subunit; serine/threonine protein phosphatase catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 32 Source/Isotype: Rabbit IgG