CST, 65178T, SLC44A1 (F8D3V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SLC44A1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SLC44A1 (F8D3V) Rabbit Monoclonal Antibody (CST #65178) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity SLC44A1 (F8D3V) Rabbit Monoclonal Antibody recognizes endogenous levels of total SLC44A1/CTL1 protein. This antibody detects a 300 kDa protein of unknown identity in some cell lines. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro612 of human SLC44A1/CTL1 protein. Background Solute carrier family 44 member 1 (SLC44A1), also known as choline transporter-like protein 1 (CTL1), is a high-affinity choline transporter. SLC44A1/CTL1 is a member of the SLC44A family of transporters that may function to transport choline across the cell membrane (1). SLC44A1/CTL1, a membrane protein with nine transmembrane domains, is the only SLC44A family member firmly established as an Na+-independent choline transporter (2). SLC44A1/CTL1 is widely expressed in the nervous system in both neurons and oligodendrocytes. Choline transport into the cell is important for acetylcholine synthesis at cholinergic nerve endings. Moreover, choline is important for the synthesis of phospholipids that make up cell membranes. Abnormal choline transport and metabolism are implicated in several neurodegenerative diseases, and SLC44A1/CTL1, specifically, is genetically linked to a rare childhood-onset neurodegenerative disease characterized by various forms of cognitive and physical deficiencies (3,4). Alternate Names CD92; CD92 protein; CDW92; CDW92 antigen; Choline transporter-like protein 1; CHTL1; CONATOC; CTL1; RP11-287A8.1; SLC44A1; solute carrier family 44 (choline transporter), member 1; Solute carrier family 44 member 1; solute carrier family 44, member 1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 60 Source/Isotype: Rabbit IgG