CST, 65699S, NY-ESO-1 (D1Q2U) Rabbit Monoclonal Antibody (PE Conjugate)

Monoclonal Antibody for studying CTAG1B. Validated for Flow Cytometry (Fixed/Permeabilized). Highly specific and rigorously validated in-house, NY-ESO-1 (D1Q2U) Rabbit Monoclonal Antibody (PE Conjugate) (CST #65699) is ready to ship. Product Usage Information Flow Cytometry (Fixed/Permeabilized): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity NY-ESO-1 (D1Q2U) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total NY-ESO-1 protein. This antibody conjugate cross-reacts with NY-ESO-2/LAGE-1S. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NY-ESO-1 protein, isoform 1. Background Cancer/testis antigens (CTAs) are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregulated in a wide variety of human solid and liquid tumors (1,2). As such, CTAs have garnered much attention as attractive targets for a variety of immunotherapy-based approaches to selectively attack tumors (3). Alternate Names Autoimmunogenic cancer/testis antigen NY-ESO-1; cancer antigen 3; Cancer/testis antigen 1; cancer/testis antigen 1B; Cancer/testis antigen 6.1; CT6.1; CTAG; CTAG1; CTAG1A; CTAG1B; CTG1B; ESO1; L antigen family member 2; LAGE-2; LAGE2; LAGE2A; LAGE2B; New York esophageal squamous cell carcinoma 1; NY-ESO-1 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG