CST, 66825T, CXCR4 (F1K2M) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CXCR4 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CXCR4 (F1K2M) Rabbit Monoclonal Antibody (CST #66825) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:50 - 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity CXCR4 (F1K2M) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCR4 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly187 of mouse CXCR4 protein. Background CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied as a potential therapeutic target in the context of autoimmune diseases (3), as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4). Alternate Names b2b220C; b2b220Clo; C-X-C chemokine receptor type 4; CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; Cmka; Cmkar4; CXC-R4; CXCR-4; Cxcr4; Fusin; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; OTTMUSP00000022912; PB-C; PB-CKR; PBSF/SDF-1; Pre-B-cell-derived chemokine receptor; Sdf; SDF-1 receptor; Sdf1r; Stromal cell-derived factor 1 receptor Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 30-50 Source/Isotype: Rabbit IgG