CST, 66935S, MAOA Antibody

Polyclonal Antibody for studying MAOA. Validated for Western Blotting. Highly specific and rigorously validated in-house, MAOA Antibody (CST #66935) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MAOA Antibody recognizes endogenous levels of total MAOA protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro243 of human MAOA protein. Antibodies are purified by peptide affinity chromatography. Background Monoamine oxidase A (MAOA), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAOA promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network (1). In addition, MAOA expression in adipose tissue macrophages is upregulated in aging, leading to the reduction of noradrenaline availability in adipose tissue. Decreased levels of noradrenaline contribute to the aging-related decline of catecholamine-induced lipolysis in adipocytes (2). Furthermore, sympathetic neuron-associated macrophages import and degrade norepinephrine via the transporter SLC6A2 and MAOA, respectively, and thus contribute to obesity (3). Alternate Names Amine oxidase [flavin-containing] A; AOFA; BRNRS; MAO-A; MAOA; Monoamine oxidase; monoamine oxidase A; Monoamine oxidase type A Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 62 SOURCE: Rabbit