CST, 67145S, CXCR5 (E3G3A) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)

Monoclonal Antibody for studying CXCR5 mouse. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, CXCR5 (E3G3A) Rabbit Monoclonal Antibody (Alexa Fluor^® 647 Conjugate) (CST #67145) is ready to ship. Product Usage Information Flow Cytometry (Live): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Live) Specificity / Sensitivity CXCR5 (E3G3A) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of mouse CXCR5 protein. Background CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration toward secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4). Alternate Names Blr1; Burkitt lymphoma receptor 1 homolog; C-X-C chemokine receptor type 5; CD185; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC-R5; CXCR-; CXCR-5; Cxcr5; Gpc; Gpcr6; MDR15 Specification REACTIVITY: M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG