CST, 67189S, Liprin beta1 (D6O4Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying liprin beta 1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Liprin beta1 (D6O4Z) Rabbit Monoclonal Antibody (CST #67189) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Liprin beta1 (D6O4Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total Liprin β1 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly528 of human Liprin β1 protein. Background Liprins are a family of proteins known to function as LAR (leukocyte common antigen-related) transmembrane protein tyrosine phosphatase-interacting proteins (1). This interaction has been studied in connection to both axon guidance and mammary gland development (1,2). Liprin β1, a member of this family, is a widely expressed, multivalent cytosolic protein. Liprin β1 has been found to homodimerize at the N terminus and to heterodimerize with Liprin α1 and the metastasis-associated protein S100A4 at the C terminus (1,2). The interaction with S100A4 is believed to both inhibit its phosphorylation and to modulate complex formation with Liprin α1, resulting in a change in LAR cell adhesion properties, thus promoting cell motility and tumor metastasis (2). Liprin β1 has also been shown to have higher expression levels and to associate with KANK proteins in melanoma and to be a potential regulator of lymphatic vessel integrity (3,4). Alternate Names hSGT2; hSgt2p; KIAA1230; L2; LIPB1; liprin beta 1; liprin related protein; liprin-beta 1; Liprin-beta-1; PPFIA binding protein 1; PPFIBP1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1; PTPRF interacting protein, binding protein 1 (liprin beta 1); PTPRF-interacting protein-binding protein 1; SGT2 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 135 Source/Isotype: Rabbit IgG