CST, 67380S, Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SCRN1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody (CST #67380) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total secernin-1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro335 of human secernin-1 protein. Background Secernin-1, encoded by the gene , is a 50 kDa cytosolic protein implicated in a variety of biological functions. Originally discovered as a protein that regulates mast cell exocytosis, secernin-1 has been suggested to play roles in axon growth, endoplasmic reticulum (ER) remodeling, and presynaptic vesicle recycling (1-3). In Alzheimer's disease (AD), secernin-1 was found to be abundant within amyloid plaques of dystrophic neurites and in neurofibrillary tangles (NFTs). Co-immunoprecipitation of secernin-1 and phosphorylated tau from AD patient brain samples further suggests a direct interaction between these proteins (4,5). Secernin-1 levels were also found to be increased in the cerebrospinal fluid (CSF) of AD patients, correlating with total and phospho-tau levels, suggesting its potential as a diagnostic and prognostic biofluid biomarker (6). Beyond AD, has been identified as a tumor-associated gene, with expression levels implicated in the development and progression of various cancers (7-9). Alternate Names KIAA0193; SCRN1; secernin 1; Secernin-1; SES1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 50 Source/Isotype: Rabbit IgG