CST, 68046T, Synaptoporin (F6H2E) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SYNPR mouse. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Synaptoporin (F6H2E) Rabbit Monoclonal Antibody (CST #68046) is ready to ship. Product Usage Information Immunofluorescence (Frozen): 1:400 - 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunofluorescence (Frozen) Specificity / Sensitivity Synaptoporin (F6H2E) Rabbit mAb recognizes endogenous levels of total synaptoporin protein. Nonspecific staining of fixed frozen mouse kidney may be observed by immunofluorescence. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse synaptoporin protein. Background Synaptoporin, also known as synaptophysin II, has been identified as an isoform of synaptophysin in small synaptic vesicles; it shares 58% homology with synaptophysin (1,2). Synaptoporin and synaptophysin are N-glycosylated membrane proteins that are part of a heteromultimeric complex in synaptic vesicle membranes (2). In general, synaptophysin is more widely distributed in most areas of the nervous system, whereas synaptoporin expression is restricted in some subareas, e.g., forebrain and spinal cord (2-4). After peripheral nerve injury, synaptoporin expression is upregulated in small dorsal root ganglion neurons and appears to play a role in both physiological and neuropathic pain states (5). Alternate Names 1500003F20Rik; SPO; Synaptoporin; synaptorin; Synpr Specification REACTIVITY: M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG1