CST, 68095S, M-Sec/TNFAIP2 (F7G3U) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TNFAIP2. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, M-Sec/TNFAIP2 (F7G3U) Rabbit Monoclonal Antibody (CST #68095) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity M-Sec/TNFAIP2 (F7G3U) Rabbit Monoclonal Antibody recognizes endogenous levels of total M-Sec/TNFAIP2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human M-Sec/TNFAIP2 protein. Background M-Sec, also known as tumor necrosis factor alpha-induced protein 2 (TNFAIP2), is a cytosolic protein required for the formation of tunneling nanotubes (TNTs), thin channels between cells that play a variety of functions, including transfer of RNA, organelles, and pathogens (1-3). By interacting with RalA, M-Sec/TNFAIP2 triggers polymerization of F-actin to form TNTs (4,5). M-Sec/TNFAIP2 expression can be induced by exposure to inflammatory cytokines and retinoic acid, and outside of disease contexts, the protein is mainly expressed in endothelial and immune cells (6,7). Upregulation of M-Sec/TNFAIP2 has been reported in several types of cancer. It contributes to metastasis and angiogenesis, and it may serve as a biomarker and prognostic marker in a subset of cancers, including acute myeloid leukemia and triple-negative breast cancer (8-10). Alternate Names B94; EXOC3L3; exocyst complex component 3-like 3; Primary response gene B94 protein; TNAP2; TNF alpha induced protein 2; TNF alpha-induced protein 2; TNFAIP2; Tumor necrosis factor alpha-induced protein 2; tumor necrosis factor, alpha induced protein 2; tumor necrosis factor, alpha-induced protein 2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 73 Source/Isotype: Rabbit IgG