CST, 68488S, MEIS2 (F9I5S) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Meis2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MEIS2 (F9I5S) Rabbit Monoclonal Antibody (CST #68488) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MEIS2 (F9I5S) Rabbit Monoclonal Antibody recognizes endogenous levels of total MEIS2 protein. This antibody does not cross-react with MEIS1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro414 of human MEIS2 protein. Background Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain-containing proteins are frequently involved in normal developmental processes but can also be associated with tumorigenic states (1). MEIS proteins belong to the three amino acid loop extension (TALE) homeobox-containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3), while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5). Alternate Names CPCMR; Homeobox protein Meis2; HsT18361; Meis homeobox 2; Meis homolog 2; Meis1-related gene 1; Meis1-related protein 1; Meis1, myeloid ecotropic viral integration site 1 homolog 2; MEIS2; MGC2820; MRG1; TALE homeobox protein Meis2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 65 Source/Isotype: Rabbit IgG