CST, 69101S, G3bp1 Antibody

Polyclonal Antibody for studying G3BP-1 mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, G3bp1 Antibody (CST #69101) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity G3bp1 Antibody recognizes endogenous levels of total G3bp1 protein. This antibody does not cross-react with G3bp2 protein. Species Reactivity: Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse G3bp1 protein. Antibodies are purified by peptide affinity chromatography. Background Ras GTPase-activating protein-binding protein 1, also known as GAP SH3 domain-binding protein 1 (G3BP1), was identified as a protein that interacts with the SH3 domain of Ras GTPase-activating protein (RasGap) (1). G3BP1 is involved in the regulation of multiple cellular processes, including mRNA decay and inhibition of translation initiation (2). Furthermore, G3BP1 is essential for the assembly of stress granules (SGs) and functions as an SG-nucleating protein (3). Research studies show that arginine demethylation of G3BP1 promotes SG assembly during oxidative stress (4). Alternate Names AI849976; ATP-dependent DNA helicase VIII; B430204O07; C87777; G3bp; G3BP-1; G3bp1; GAP SH3 binding protein; GAP SH3 domain-binding protein 1; GTPase activating protein (SH3 domain) binding protein 1; HDH-VIII; KIAA4115; mKIAA4115; OTTMUSP00000005871; Ras GTPase-activating protein-binding protein 1; Ras-GTPase-activating protein SH3-domain binding protein 1 Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 68 SOURCE: Rabbit