CST, 69240S, LYVE-1 (E3L3V) Rabbit Monoclonal Antibody (Alexa Fluor® 488 Conjugate)

Monoclonal Antibody for studying LYVE-1 mouse. Validated for Immunofluorescence (Frozen). Highly specific and rigorously validated in-house, LYVE-1 (E3L3V) Rabbit Monoclonal Antibody (Alexa Fluor^® 488 Conjugate) (CST #69240) is ready to ship. Product Usage Information Immunofluorescence (Frozen): 1:50 - 1:100 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunofluorescence (Frozen) Specificity / Sensitivity LYVE-1 (E3L3V) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse LYVE-1 protein. Background Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), also known as extracellular link domain-containing protein 1 (XLKD1), is a type I integral membrane glycoprotein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells, but has also been described on hepatic blood sinusoidal endothelia, embryonic blood vessels, Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium (1-3). LYVE-1 acts as a receptor for hyaluronan, and plays a role in hyaluronan transport and turnover (4-7). LYVE-1 also mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to hyaluronan in the leukocyte surface glycocalyx (8). Several studies have demonstrated the utility of LYVE-1 as a marker for lymphoid tissues and lymphangiogenesis (9,10). Alternate Names 1200012G08Rik; cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Crsbp1; extra cellular link domain-containing 1; Extracellular link domain-containing protein 1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; Lyve; LYVE-1; Lyve1; Xlkd; Xlkd1 Specification REACTIVITY: M R SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG