CST, 6932T, CTDSPL2 (D79G11) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CTDSPL2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CTDSPL2 (D79G11) Rabbit Monoclonal Antibody (CST #6932) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CTDSPL2 (D79G11) Rabbit Monoclonal Antibody recognizes endogenous levels of total CTDSPL2 protein. Species Reactivity: Human, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CTDSPL2 protein. Background CTD small phosphatase-like protein 2 (CTDSPL2, HSPC129) is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase (1) that belongs to a small subfamily of CTD phosphatases (2). The CTD of RNA polymerase II contains multiple Y-S-P-T-S-P-S repeats that are phosphorylated during the transcription cycle (3,4). In general, CTD phosphatases regulate the reversible CTD phosphorylation state of RNA-polymerase II at several stages of RNA synthesis and during post-transcriptional modification (4-6). CTDSPL2 has several structural and functional similarities to other CTD phosphatases, including FCP1, SCP1, DULLARD, and UBLCP1 (1,2). Alternate Names CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; CTD small phosphatase like 2; CTD small phosphatase-like protein 2; CTDSP-like 2; CTDSPL2; CTSL2; FLJ10523; HSPC058; HSPC129; SCP4 Specification REACTIVITY: H R Mk SENSITIVITY: Endogenous MW (kDa): 62 Source/Isotype: Rabbit IgG