CST, 69721S, YKL-40 (F9N3K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CHI3L1 mouse. Validated for Immunoprecipitation,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, YKL-40 (F9N3K) Rabbit Monoclonal Antibody (CST #69721) is ready to ship. Product Usage Information Immunoprecipitation: 1:100 Immunofluorescence (Frozen): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunoprecipitation, Immunofluorescence (Frozen) Specificity / Sensitivity YKL-40 (F9N3K) Rabbit mAb recognizes endogenous levels of total YKL-40 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse YKL-40 protein. Background YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein encoded by the gene (1,2). Unlike other members of the chitinase-like protein family, YKL-40 is not an active chitinase. It is produced by activated macrophages, chondrocytes, neutrophils, and synovial cells. It is a pro-inflammatory molecule that contributes to the progression of many inflammatory diseases, including fibrosis, neurodegenerative disease, breast, lung, prostate, liver, bladder, colon, and other types of cancers (3,4). Levels of YKL-40 in serum and plasma in patients with various types of tumors have been reported to predict poor prognosis, and in some clinical assays, YKL-40 is being used as a predictive biomarker of cancer outcome (4). Alternate Names AW208766; Breast regression protein 39; Brp; Brp39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CH3L1; Chi3; Chi3l1; Chil1; chitinase 3 like 1; chitinase 3-like 1; Chitinase-3-like protein 1; chitinase-like 1; GP-39; Gp3; Gp39 Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 44 Source/Isotype: Rabbit IgG