CST, 71825S, BTNL9 (F2F8S) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying BTNL9. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, BTNL9 (F2F8S) Rabbit Monoclonal Antibody (CST #71825) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity BTNL9 (F2F8S) Rabbit Monoclonal Antibody recognizes transfected levels of BTNL9 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu522 of human BTNL9 protein. Background Butyrophilin-like (BTNL) proteins are part of the immunoglobulin superfamily and are structurally related to B7 proteins that comprise co-stimulatory and co-inhibitory molecules that regulate T cells. Five BTNL family members have been identified in humans, and eight in mice (1). BTNL proteins play an important role in regulating γδT cells, and BTNL-fc fusion proteins and soluble BTNL molecules have been shown to inhibit T cell activation (2,3). The BTNL family member, BTNL9, has been identified as a prognostic marker and possible therapeutic target in multiple malignancies, including uveal melanoma, breast cancer, lung adenocarcinoma (LUAD), and thyroid cancer (4-7). Alternate Names BTN3; BTN8; BTNL9; butyrophilin 3; butyrophilin like 9; butyrophilin-like 9; Butyrophilin-like protein 9; OTTHUMP00000082750; Q6UXG8; VDLS1900 Specification REACTIVITY: H SENSITIVITY: Transfected Only MW (kDa): 70 Source/Isotype: Rabbit IgG