CST, 72054S, KIFC1 Antibody

Polyclonal Antibody for studying KIFC1. Validated for Western Blotting. Highly specific and rigorously validated in-house, KIFC1 Antibody (CST #72054) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity KIFC1 Antibody recognizes endogenous levels of total KIFC1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala668 of human KIFC1 protein. Antibodies are purified by peptide affinity chromatography. Background Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g., proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function such as learning and memory (4-6). Kinesin family member C1 (KIFC1/HSET) is a minus-end-directed KIF involved in the processing and movement of early endocytic vesicles (7,8), as well as microtubule cross-linking and spindle assembly (9,10). Alternate Names HSET; KIFC1; kinesin family member C1; kinesin-like 2; Kinesin-like protein 2; Kinesin-like protein KIFC1; Kinesin-related protein HSET; KNSL2; MGC1202; MGC149736; MGC149737 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 75 SOURCE: Rabbit