CST, 72172S, CXCR5 (D6L3C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CXCR5. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CXCR5 (D6L3C) Rabbit Monoclonal Antibody (CST #72172) is ready to ship. Product Usage Information IHC Leica Bond: 1:50 - 1:200 Immunohistochemistry (Paraffin): 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product # 99825 Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity CXCR5 (D6L3C) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCR5 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domains of human CXCR5 protein. Background CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration toward secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4). Alternate Names BLR1; Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C-X-C chemokine receptor type 5; C-X-C motif chemokine receptor 5; CD185; chemokine (C-X-C motif) receptor 5; CXC-R5; CXCR-5; CXCR5; MDR-15; MDR15; MGC117347; Monocyte-derived receptor 15 Specification REACTIVITY: H SENSITIVITY: Endogenous (IHC-P) Source/Isotype: Rabbit IgG