CST, 72247S, INSM1 (BLR272L) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying INSM1. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, INSM1 (BLR272L) Rabbit Monoclonal Antibody (CST #72247) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:800 - 1:3200 Storage Supplied in a PBS-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity INSM1 (BLR272L) Rabbit Monoclonal Antibody recognizes endogenous levels of INSM1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a peptide representing a region between residue 50 and 100 of human INSM1 protein. Background Insulinoma-associated protein 1 (INSM1), originally named IA-1, is a zinc-finger protein cloned from an insulinoma and glucagonoma subtraction library (1). It is a transcriptional repressor expressed in the developing pancreas and nervous system and targets genes such as β and insulin, critical regulators of neuroendocrine differentiation during development (2-5). Most importantly, INSM1 has emerged as a key marker in neuroendocrine tumor types, including small cell lung cancer (SCLC), medullary thyroid carcinoma, pheochromocytoma, Merkel cell carcinoma, neuroblastoma, and neuroendocrine tumors of the pancreas, breast, colon, bladder, and prostate (6-9). Some studies have also shown that the level of INSM1 expression may have prognostic value (10,11). Alternate Names IA-1; IA1; INSM transcriptional repressor 1; INSM1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG