CST, 72602S, Somatostatin (F8W1R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SST. Validated for Western Blotting,Immunohistochemistry (Paraffin),Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Somatostatin (F8W1R) Rabbit Monoclonal Antibody (CST #72602) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:100 - 1:200 Immunofluorescence (Frozen): 1:100 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen) Specificity / Sensitivity Somatostatin (F8W1R) Rabbit Monoclonal Antibody recognizes endogenous levels of total somatostatin protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human somatostatin protein. Background Somatostatin (SST) is a small neuropeptide, originally identified to inhibit the release of growth hormone from the hypothalamus (1). SST is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein marker of inhibitory interneurons (2). Besides the central nervous system (CNS), SST is expressed in various organs, such as the pancreas, gut, and immune cells (2,3). There are two types of biologically active SST isoforms that vary in constituent amino acids: SST-14 and SST-28. Generally, SST-14 is more predominant in the CNS, whereas SST-28 is more abundant in peripheral body organs (3). Reduction of SST expression has been proposed as a hallmark of various pathological conditions such as Alzheimer's disease, schizophrenia, epilepsy, and depression (4,5,6,7). Alternate Names Growth hormone release-inhibiting factor; Neuronostatin; NST; prepro-somatostatin; SMS; SMST; Somatostatin; Somatostatin-14; Somatostatin-28; SST; SST-14 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 13 Source/Isotype: Rabbit IgG