CST, 72847S, NKG7 (F4V5I) Rabbit Monoclonal Antibody (Alexa Fluor® 488 Conjugate)

Monoclonal Antibody for studying NKG7. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, NKG7 (F4V5I) Rabbit Monoclonal Antibody (Alexa Fluor^® 488 Conjugate) (CST #72847) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity NKG7 (F4V5I) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly161 of human NKG7 protein. Background Natural killer cell granule protein 7 (NKG7, also known as GMP-17 and GIG-I) is a novel type 1 integral membrane protein expressed at high levels in lymphocytes, including natural killer (NK) cells, γδ T cells, a subset of αβ T cells, lymphokine-activated killer (LAK) cells (1), and activated T regulatory cells (2). NKG7 expression can be induced in neutrophils following GM-CSF treatment (3). NKG7 protein is localized to the membranes of cytotoxic granules. Following target cell-induced NK cell degranulation, NKG7 translocates from granules to the plasma membrane (4). Studies have also shown that NKG7 is significantly upregulated in allograft rejection patients (5-8). Alternate Names G-CSF-induced gene 1 protein; GIG-1 protein; GIG1; GMP-17; granule membrane protein 17; Granule membrane protein of 17 kDa; natural killer cell granule protein 7; natural killer cell group 7 sequence; Natural killer cell protein 7; NKG7; p15-TIA-1; Protein NKG7; Q16617 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG