CST, 72997S, Ivermectin

Chemical Modulators for studying in the research area. Product Usage Information Ivermectin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 1.14 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background Ivermectin is a positive allosteric modulator of the ATP-activated ion channel, P2X purinoceptor 4 (P2X4), as well as the α7 neuronal nicotinic acetylcholine receptor (α7-nAChR) (1,2). The α7-nAChR is required for the cytokine suppressing mechanism of the inflammatory reflex and it stimulates activation of calcium ion transport. Impairment of the α7-nAChR can lead to overproduction of cytokines and a heightened inflammatory response (3). Ivermectin is a known anthelmintic agent, activating the glutamate-gated chloride channels in the nerves and muscles of parasites. The disruption of the parasite's ingestive activity eventually leads to starvation (4). Ivermectin has been shown to inhibit SARS-CoV-2 replication with an IC value of ~2 μM (5). Alternate Names 2223-Dihydro C076B1; 2223-Dihydroavermectin B1; MK-933