CST, 73561S, ITM2A (E7G8A) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ITM2A. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, ITM2A (E7G8A) Rabbit Monoclonal Antibody (CST #73561) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunofluorescence (Immunocytochemistry): 1:6400 - 1:25600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 75633 . Protocol Available protocols: Western Blotting, Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity ITM2A (E7G8A) Rabbit Monoclonal Antibody recognizes endogenous levels of total ITM2A protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human ITM2A protein. Background Integral membrane protein 2A (ITM2A) is a type II membrane protein. ITM2A belongs to a family of membrane proteins defined by a conserved BRICHOS domain, a stretch of approximately 100 amino acids that may function as chaperone proteins (1). ITM2A, like other BRICHOS domain-containing proteins, may undergo proteolytic cleavage as it matures (2,3). BRICHOS domain-containing proteins exhibit anti-amyloidogenic activity, suggesting that these proteins may modulate formation of amyloid fibrils and oligomers (4). Aberrant amyloid formation is associated with amyloid diseases like Alzheimer's disease. The specific function of ITM2A is unclear but it may play a redundant role in the development and function of T cells (5). Alternate Names BRICD2A; BRICHOS domain containing 2A; E25A; Integral membrane protein 2A; ITM2A; Protein E25 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 12, 39 Source/Isotype: Rabbit IgG