CST, 74444S, SYNGR3 Antibody

Polyclonal Antibody for studying SYNGR3. Validated for Western Blotting. Highly specific and rigorously validated in-house, SYNGR3 Antibody (CST #74444) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity SYNGR3 Antibody recognizes endogenous levels of total synaptogyrin-3 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu206 of human synaptogyrin-3 protein. Antibodies are purified by peptide affinity chromatography. Background Synaptogyrin, or SYNGR, are a family of tyrosine-phosphorylated proteins, including neuronal SYNGR1 and SYNGR3 that are found in synaptic vesicles and contribute to the proper synapse function. Synaptogyrin-2 (SYNGR2) expresses ubiquitously and it is not only associated with synaptic vesicles, but also plays an important role in exocytosis processes (1,3). In addition, it has been shown that SYNGRs modulate calcium currents in excitable cells during potassium chloride-dependent exocytosis (3). SYNGR3 and SYNGR1 specifically localize in synaptic vesicles. SYNGR1 modulates synaptic vesicle function similar to SYNGR3 (2,3). SYNGR1 and SYNGR3 contribute to the neurotransmitter release in neurons by interactions with the GABA and VGLUT transporters in primary neurons and in C. elegans (4-6). SYNGRs are associated with disease including Schizophrenia (7,8) and Alzheimer's disease (9,10). Alternate Names MGC:20003; SNG3; synaptogyrin 3; Synaptogyrin-3; SYNGR3 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 26 SOURCE: Rabbit