CST, 74748S, Kv4.2 (D3E7G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Kv4.2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Kv4.2 (D3E7G) Rabbit Monoclonal Antibody (CST #74748) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Kv4.2 (D3E7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total Kv4.2 protein. This antibody does not cross-react with Kv4.1 and Kv4.3 proteins. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Kv4.2 protein. Background Kv4.2 is a voltage-gated potassium channel that belongs to the Shal-related subfamily. Kv4.2 mediates K+ transport in excitable membranes primarily in the brain, where it regulates neuronal excitability, synaptic plasticity, and the circadian rhythm of locomotor activity (1-6). In rodent heart, Kv4.2 mediates the transient outward current (Ito), which contributes to early repolarization and the cardiac action potential (7). Kv4.2 can form homotetramers or heterotetramers with other members of the Shal-related subfamily. Interaction with modulating β subunits such as KChIP family proteins modulates Kv4.2 expression at cell surface and its channel activity (8-10). Alternate Names KCND2; KIAA1044; KV4.2; MGC119702; MGC119703; potassium channel, voltage gated Shal related subfamily D, member 2; Potassium voltage-gated channel subfamily D member 2; potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 70 Source/Isotype: Rabbit IgG