CST, 76069T, CD21/CR2 (2G9) Mouse Monoclonal Antibody

Monoclonal Antibody for studying CR2. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD21/CR2 (2G9) Mouse Monoclonal Antibody (CST #76069) is ready to ship. Product Usage Information IHC Leica Bond: 1:200 - 1:800 Immunohistochemistry (Paraffin): 1:50 - 1:200 Storage Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity CD21/CR2 (2G9) Mouse Monoclonal Antibody recognizes endogenous levels of CD21/CR2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to the external domain of human CD21/CR2 protein. Background Complement receptor type 2 (CD21/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9). Alternate Names C3DR; CD21; Complement C3d receptor; complement C3d receptor 2; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; Complement receptor type 2; CR; CR2; CVID7; EBV receptor; Epstein-Barr virus receptor; SLEB9 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG2a