CST, 76607S, MT-ATP6 (F9Y8D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MT-ATP6. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MT-ATP6 (F9Y8D) Rabbit Monoclonal Antibody (CST #76607) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MT-ATP6 (F9Y8D) Rabbit Monoclonal Antibody recognizes endogenous levels of total MT-ATP6 protein. Species Reactivity: Human, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys35 of human MT-ATP6 protein. Background Mitochondrially-encoded ATP Synthase Membrane Subunit 6 (MT-ATP6) is a product of , one of 13 protein-encoding genes in the mitochondrial genome. MT-ATP6 comprises one subunit of the transmembrane F F ATP synthase (Complex V), which catalyzes the final step of oxidative phosphorylation in the electron transport chain (1). Numerous mutations in the gene have been identified that lead to defects in oxidative phosphorylation. Many of these are strongly associated with distinct disease states, including Leigh syndrome (2) and Charcot-Marie-Tooth (CMT) disease (3). Alternate Names ATP synthase F0 subunit 6; ATP synthase subunit a; ATP6; ATPASE6; F-ATPase protein 6; mitochondrially encoded ATP synthase 6; MT-ATP6; MTATP6 Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 20 Source/Isotype: Rabbit IgG