CST, 76924S, CCL20 (E6J9K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CCL20. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CCL20 (E6J9K) Rabbit Monoclonal Antibody (CST #76924) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CCL20 (E6J9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total CCL20 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human CCL20 protein. Background Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a chemokine that mediates leukocyte migration during inflammation and homeostasis (1-3). CCL20 is expressed by T helper (Th) 17 cells (Th17), B cells, natural killer cells, neutrophils, dendritic cells (DC), macrophages, and endothelial cells (4-6). Its receptor, C-C chemokine receptor 6 (CCR6), is expressed by immune cells, such as regulatory CD4+ T cells (Tregs), Th17 cells, CD8+ T cells, and B cells, and drives their migration into CCL20 rich tissues (7). In induced Tregs, CCL20 ligation with its receptor suppresses Treg function via signaling through the AKT/mTOR/STAT3 axis (8). The CCR6-CCL20 axis is being investigated as a therapeutic target for its role in autoimmune disease, viral infection, and cancer progression (7,9). Alternate Names beta chemokine exodus-1; Beta-chemokine exodus-1; C-C motif chemokine 20; C-C motif chemokine ligand 20; CC chemokine LARC; CCL20; CCL20(1-64); CCL20(1-67); CCL20(2-70); chemokine (C-C motif) ligand 20; CKb4; Exodus; LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; MIP-3a; MIP3A; SCYA20; small inducible cytokine subfamily A (Cys-Cys), member 20; Small-inducible cytokine A20; ST38 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 9 Source/Isotype: Rabbit IgG