CST, 78043T, IFIT2 (F8P1H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IFIT2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, IFIT2 (F8P1H) Rabbit Monoclonal Antibody (CST #78043) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity IFIT2 (F8P1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFIT2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IFIT2 protein. Background IFIT2 (Interferon-induced protein with tetratricopeptide repeats 2, ISG54) belongs to the IFIT family of proteins, which consists of four members in humans (IFIT1, IFIT2, IFIT3, and IFIT5) and three members in mice (IFIT1, IFIT2, and IFIT3) (1). IFIT2 expression is transiently induced by exposure to interferons, double-stranded RNA, or viruses (2). IFIT2 has been shown to inhibit translation by binding to the eukaryotic initiation factor 3 (eIF3) (2). In addition, IFIT2 forms a multiprotein complex with the related proteins IFIT1 and IFIT3, which stimulates cell death via a mitochondrial pathway and prevents viral replication (1,3). Alternate Names CIG-42; cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; IFIT2; interferon induced protein with tetratricopeptide repeats 2; Interferon-induced 54 kDa protein; interferon-induced protein 54; Interferon-induced protein with tetratricopeptide repeats 2; Interferon, alpha-inducible protein (MW 54kD); ISG-54 K; ISG-54K; ISG54; P54 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 55 Source/Isotype: Rabbit IgG