CST, 79322T, SORL1 (D8D4G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SORL1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SORL1 (D8D4G) Rabbit Monoclonal Antibody (CST #79322) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity SORL1 (D8D4G) Rabbit Monoclonal Antibody recognizes endogenous levels of total SORL1 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu267 of human SORL1 protein. Background SORL1, also called SorLA, is a 250 kDa type-1 membrane protein found in neurons of the central and peripheral nervous system (1). SORL1 is related to the yeast transporter Vps10p (2). While its exact function is unknown, because it shuttles between the Golgi apparatus and endolysosomal compartments, and given its structural similarity with Vps10p, it has been suggested that SORL1 acts in intracellular trafficking (3). Interestingly, SORL1 expression has been shown to be decreased in the brain of patients with Alzheimer's disease (4), and research studies have demonstrated a role for SORL1 as a neuronal sorting receptor that binds APP and regulates its trafficking and proteolytic processing, thus regulating the production of amyloid-beta peptides (5). Alternate Names C11orf32; FLJ21930; FLJ39258; gp250; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LRP9; mosaic protein LR11; SORL; SORL1; SorLA; SorLA-1; sortilin related receptor 1; Sortilin-related receptor; sortilin-related receptor containing LDLR class A repeats; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; Sorting protein-related receptor containing LDLR class A repeats Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 250 Source/Isotype: Rabbit IgG