CST, 79418S, Prolactin (F1H6N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Prolactin. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, Prolactin (F1H6N) Rabbit Monoclonal Antibody (CST #79418) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Prolactin (F1H6N) Rabbit Monoclonal Antibody recognizes endogenous levels of total prolactin protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human prolactin protein. Background Prolactin (PRL) is a polypeptide hormone generated and secreted by lactotrophic cells of the anterior pituitary gland (1). The hormone's main function is to promote lactation in response to the suckling reflex. It is involved in many other biological processes, including reproduction, metabolism, autoimmunity, diabetes, and cancer development (2-7). The major isoform, 23 kDa prolactin, acts via binding to its membrane receptor, the prolactin receptor (PRLR). PRLR is a member of the hematopoietic cytokine superfamily and its activation mechanism has been linked to the Jak2 pathway (8). Alternate Names decidual prolactin; GHA1; growth hormone A1; PRL; Prolactin Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 24 Source/Isotype: Rabbit IgG