CST, 79516S, CCDC124 (E2G4Q) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CCDC124. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CCDC124 (E2G4Q) Rabbit Monoclonal Antibody (CST #79516) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity CCDC124 (E2G4Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total CCDC124 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCDC124 protein. Background Translation is reversibly shut down in cells that are deprived of nutrients. In these cells, ribosomes bind to inhibitory factors and are kept inactive. After nutrient deprivation, translation recovers. CCDC124 (coiled-coil domain-containing protein 124/coiled-coil domain-containing short open reading frame 124) plays an active role in translation recovery after starvation (1). In addition, research studies show that the non-structural protein 1 (Nsp1) from SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) associates with ribosomes and shuts down host protein translation. CCDC124 is in one of the two major populations of translationally inactive ribosomes in the Nsp1-bound 80S complexes (2). Alternate Names CC124; CCDC124; coiled-coil domain containing 124; Coiled-coil domain-containing protein 124 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 28 Source/Isotype: Rabbit IgG