CST, 80302S, Mfsd2a (E8U2O) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MFSD2A mouse. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Mfsd2a (E8U2O) Rabbit Monoclonal Antibody (CST #80302) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Immunofluorescence (Frozen): 1:600 - 1:1200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Frozen) Specificity / Sensitivity Mfsd2a (E8U2O) Rabbit Monoclonal Antibody recognizes endogenous levels of total Mfsd2a protein. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Mfsd2a protein. Background Mfsd2a is a sodium-dependent lysophosphatidylcholine symporter (1). It regulates lipid metabolism, growth and development, and motor function (2). It transports lysophosphatidylcholines consisting of omega-3 fatty acid docosahexaenoic acid (DHA) or other long-chain fatty acids. Mfsd2a was shown to be critical for the brain to take up DHA from plasma (3). Furthermore, Mfsd2a is required for the blood-brain barrier (BBB) formation and function (4). Lipids transported into endothelial cells in the central nervous system by Mfsd2a form a lipid environment essential to maintain BBB integrity (5). Alternate Names 1700018O18Rik; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A; Major facilitator superfamily domain-containing protein 2A; MFS2A; Mfsd; Mfsd2; Mfsd2a; NLS1; OTTMUSP00000009315; Sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1 Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 50-60 Source/Isotype: Rabbit IgG