CST, 80519S, CD84 (E4F2N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CD84 mouse. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CD84 (E4F2N) Rabbit Monoclonal Antibody (CST #80519) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity CD84 (E4F2N) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD84 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD84 protein. Background Cluster of Differentiation 84 (CD84), also known as signaling lymphocytic activation molecule family member 5 (SLAMF5), is a membrane glycoprotein expressed by numerous immune cell types, including hematopoietic progenitor cells, T cells, B cells, NK cells, macrophages, monocytes, dendritic cells, platelets, mast cells, and thymocytes (1-9). CD84 is a homophilic adhesion molecule involved in modulating the activation, differentiation, proliferation, and cytotoxicity of a wide variety of immune cells, and thus is involved in the regulation and interconnection of both the innate and adaptive immune response (6-14). Certain CD84 activities are regulated by the presence or absence of small cytoplasmic adaptor proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (5,14). Alternate splicing results in multiple transcript variants. Alternate Names A130013D22Rik; Cd84; CD84 antigen; CDw84; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; SLA; SLAF5; SLAM family member 5; Slamf5 Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 45-80 Source/Isotype: Rabbit IgG