CST, 80636S, GLUL (D2O3F) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying GLUL. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, GLUL (D2O3F) Rabbit Monoclonal Antibody (CST #80636) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity GLUL (D2O3F) Rabbit Monoclonal Antibody recognizes endogenous levels of total GLUL protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala297 of human GLUL protein. Background Glutamate-ammonia ligase (GLUL), also known as glutamine synthetase (GS), catalyzes the synthesis of glutamine from glutamate and ammonia. GLUL is ubiquitously expressed with particularly high expression in the muscle, liver, and brain (1). GLUL expression is elevated in various cancers. Its expression is upregulated by oncogenic c-Myc (2). High expression of GLUL in breast cancer patients is associated with larger tumor size and high level of HER2 expression. It is a predictor of poor survival in patients with glioma and liver cancers (3-6). Alternate Names cell proliferation-inducing protein 59; GLNA; GLNS; GLUL; Glutamate decarboxylase; Glutamate--ammonia ligase; glutamate-ammonia ligase; glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; Glutamine synthetase; GS; Palmitoyltransferase GLUL; PIG43; PIG59; proliferation-inducing protein 43 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 42 Source/Isotype: Rabbit IgG