CST, 81055S, MPP6/MPHOSPH6 (F3T9S) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MPHOSPH6. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MPP6/MPHOSPH6 (F3T9S) Rabbit Monoclonal Antibody (CST #81055) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MPP6/MPHOSPH6 (F3T9S) Rabbit Monoclonal Antibody recognizes endogenous levels of total MPP6/MPHOSPH6 protein. This antibody detects 52 and 54 kDa bands of unknown origin. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala151 of human MPP6/MPHOSPH6 protein. Background M-phase phosphoprotein 6 (MPP6 or MPHOSPH6) is a nuclear exosome protein that binds to pre-rRNAs to help facilitate the formation of mature 5.8S rRNA (1-3). MPP6, along with other exosome cofactors, can recruit the RNA helicase MTR4 to facilitate decay by unwinding RNA in order for it to enter the exosome core (4-6). MPP6 and YTHDC1 have been shown to play a role in IgH DNA recombination through an m6A-dependent mechanism (7). Alternate Names M-phase phosphoprotein 6; MPH6; MPHOSPH6; MPP; MPP-6; MPP6 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 20 Source/Isotype: Rabbit IgG