CST, 81428T, LMO4 (D6V4Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LMO4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LMO4 (D6V4Z) Rabbit Monoclonal Antibody (CST #81428) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LMO4 (D6V4Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total LMO4 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LMO4 protein. Background LMO4 is a LIM zinc-binding domain-containing protein. LMO4 cDNA was first isolated from a breast tumor cDNA library (1). This transcriptional modulator is overexpressed in several epithelial cancers such as prostate, pancreas, and breast (2-4). LMO4 exhibits pro-oncogenic activities by inducing centrosome amplification and mitotic spindle abnormalities (5). LMO4 is also expressed in the brain, in regions involved in learning and the regulation of motivated behavior. In the basolateral amygdala, LMO4 functions to negatively regulate fear learning (6). Furthermore, in the nucleus accumbens, LMO4 was found to regulate the behavioral effects of cocaine (7). Alternate Names Breast tumor autoantigen; LIM domain only 4; LIM domain only protein 4; LIM domain transcription factor LMO4; LIM-only 4 protein; LMO-4; LMO4 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 16 Source/Isotype: Rabbit IgG