CST, 81692S, MUC4 beta (D4W9X) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MUC4 (beta chain). Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MUC4 beta (D4W9X) Rabbit Monoclonal Antibody (CST #81692) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:250 - 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity MUC4 beta (D4W9X) Rabbit Monoclonal Antibody recognizes endogenous levels of total MUC4 protein (β subunit). Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human MUC4 protein (β subunit). Background MUC4 is a membrane-bound mucin family member (1,2). It is a heterodimer of extracellular α subunits associated with a trans-membrane β subunit. There are 3 epidermal growth factor (EGF)-like domains in the extracellular region of the β subunit. These EGF-like domains can directly interact with ErbB2 to activate the downstream signaling pathways. MUC4 is expressed in the epithelial tissues of lung and gastrointestinal organs during development as well as in adult stage. It exerts a protective effect to these tissues against potential damage (3). Overexpression of MUC4 has been found in multiple types of cancers to promote cancer growth, survival, and metastasis (4-6). MUC4 has been proposed as a promising prognostic marker for cancer evaluation. Alternate Names Ascites sialoglycoprotein; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; ASGP; ASGP-1; ASGP-2; HSA276359; MUC-4; MUC4; mucin 4, cell surface associated; mucin 4, tracheobronchial; Mucin-4; Mucin-4 alpha chain; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 100-170 Source/Isotype: Rabbit IgG